Modular Synthesis of Biodegradable Diblock Copolymers for Designing Functional Polymersomes
نویسندگان
چکیده
منابع مشابه
Modular synthesis of biodegradable diblock copolymers for designing functional polymersomes.
Polymer vesicles, or polymersomes, are promising candidates for applications in drug delivery and tissue imaging. While a vast variety of polymers have been explored for their ability to assemble into polymersomes, relatively little research on the functionalization of these polymers has been reported. We present here a novel route for the synthesis of poly(caprolactone)-b-poly(ethylene glycol)...
متن کاملPolymersomes: tough vesicles made from diblock copolymers.
Vesicles were made from amphiphilic diblock copolymers and characterized by micromanipulation. The average molecular weight of the specific polymer studied, polyethyleneoxide-polyethylethylene (EO40-EE37), is several times greater than that of typical phospholipids in natural membranes. Both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) f...
متن کاملThe fusion mechanism of small polymersomes formed by rod-coil diblock copolymers.
The fusion mechanism of polymersomes self-assembled by rod-coil copolymers is intrinsically different from that of liposomes due to the effect of chain topology on conformational entropy and molecular packing. The influences of membrane tension, coil-block length, rod-block length, mutual compatibility between the solvent and the rod-coil block, and π-π interaction strength on the fusion pathwa...
متن کاملMembrane stabilization of biodegradable polymersomes.
Biodegradable polymersomes are promising vehicles for a range of applications. Their stabilization would improve many properties, including the retention and controlled release of polymersome contents, yet this has not been previously accomplished. Here, we present the first example of stabilizing fully biodegradable polymersomes through acrylation of the hydrophobic terminal end of polymersome...
متن کاملSynthesis and characterization of mPEG-PCL copolymers as a polymersomes for delivery of enalapril as a model hydrophilic drug
Purpose: Enalapril maleate (EPM), was used for hypertension and congestive heart failure. In this way, an innovative delivery system with mPEG–PCL was synthesized and the release profile of the EPM from the drug-loaded polymersomes was evaluated. Methods: Di-block methoxy)-poly (ethylene glycol) - Poly (caprolactone) (mPEG-PCL) copolymers were synthesized and used to prepare of polymersom...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2010
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja910606y